Dr. Demián Glujovsky recently presented at a fertility congress in São Paulo, Brazil, discussing a debated topic: the value of the DuoStim protocol.
What is DuoStim?
DuoStim involves double ovarian stimulation within the same menstrual cycle: stimulation occurs during the follicular phase, followed by egg retrieval, then a second stimulation in the luteal phase of the same cycle. The objective is retrieving more eggs quickly — eliminating the wait for the next cycle.
When is it clearly indicated?
DuoStim proves particularly beneficial in two specific situations:
- Fertility preservation in oncology patients: Time-sensitive scenarios where chemotherapy or radiotherapy must begin soon.
- Patients with significant time constraints: Those traveling internationally for treatment who need to minimize trips to Buenos Aires.
And in other cases?
For patients with diminished ovarian reserve or older age, DuoStim might lower treatment dropout rates through consecutive retrieval opportunities. However, the scientific evidence is limited, and some research shows potential selection bias affecting results.
While certain studies suggest DuoStim reduces time to obtaining a genetically normal embryo by approximately twenty days, this advantage may lack clinical significance for many patients.
Conclusion
DuoStim represents a useful option when time constraints matter significantly. Its application should rely on personalized evaluation and evidence-based medicine — not on applying it routinely to every patient.
Patients should feel empowered to discuss options openly and seek additional opinions if they wish.
