EN | ES

Chromosomal abnormalities in embryos increase with increasing age of female partner

February 25, 2014 by Dr. Demián Glujovsky
ovodonacion-1200x885.jpg

Female age is the most important single prognostic factor in an IVF cycle. It is widely known that with advancing age, live birth rates decrease, patient miscarriage rate increase and newborns with chromosomal abnormalities are increased too.

Are there new publications about it?

Yes, in Fertility and Sterility journal, a paper published by Franasiak et al evaluated the chromosomal abnormalities present in more than fifteen thousands embryos. They evaluated all the embryos obtained from 3,392 cycles, in blastocyst stage using CCS (comprehensive chromosomal screening – PGS -).

The rate of cases without any chromosomic normal embryo in women below 37 years old was 2-6%, it was over 10% at 38-39 years old, between 25-35% at 41-42 years and more than 40% in women over 43.

The rate of chromosomic normal embryos in women below 37 was over 60%, in women of 40 years old it was 50% and in women over 42 it was below 30%.

Although this information is useful, there is not specific information for women with low ovarian reserve or according to the total of available embryos. Besides, there are lots of embryos that were not evaluated just because they didn’t get to blastocyst stage, which means that real percentage of abnormal embryos should be much higher.

Two important issues for counseling:

1) proportion of embryos likely to be aneuploid. Age-specific data serve as starting point of discussion.

2) probability that all embryos will be aneuploid, leaving no embryo for transfer.  This is an important topic to discuss with patients.

Contact Us

Dr. Demián Glujovsky in CEGYR Buenos Aires
Viamonte 1432 - Buenos Aires Argentina
info@fertilityargentina.com

Newsletter




Verified Member

Fertility Argentina

EN | ES